Our Services

Our laboratory is licensed in the State of Massachusetts and the United States Federal Government under the Clinical Laboratory Improvement amendments (CLIA).

Aerodiagnostics,LLC utilizes state of the art diagnostic equipment that incorporates carbon dioxide measurements to ensure the highest quality.

We take our quality program a step further by participating in blind proficiency tests external to Aerodiagnostics,LLC.

These quality checks provide additional assurances on our tests accuracy and guards against potential variations in shipping and environmental influences.

Aerodiagnostics,LLC's Laboratory hours of operation are Monday - Friday from 9am EST to 6:30pm EST.


Small Intestinal Bacterial Overgrowth (SIBO) Test

Small Intestinal Bacterial Overgrowth (SIBO) occurs when bacteria enter your normally sterile small intestine and begin to colonize. This SIBO breath collection kit comes with either Glucose or Lactulose as a substrate. If you are requesting the test containing Lactulose, you must have your licensed clinician contact us directly to order. SIBO is a disorder of excessive bacterial growth in the small intestine. Unlike the colon (or large bowel), which is rich with bacteria. Patients with bacterial overgrowth typically develop symptoms including nausea, bloating, vomiting, diarrhea, malnutrition, weight loss and malabsorption.

Click below to access Dr. Ruscio's most recent Podcast with Dr. Siebecker and Gary Stapleton , CEO Aerodiagnostics,LLC addressing Hydrogen Sulfide SIBO, Testing & Treatment

Dr. Ruscio

Click below to access Dr. Goldenberg's survey

Dr. Ruscio


Fructose Malabsorption Test

Fructose malabsorption is a digestive disorder when absorption of fructose is impaired. This results in an increased concentration of fructose in the intestine. Occurrence is often seen in patients identified to be suffering symptoms of irritable bowel syndrome (IBS). However, due to the similarity in symptoms, patients with fructose malabsorption often fit the profile of those with irritable bowel syndrome. A small proportion of patients with both fructose malabsorption and lactose intolerance also suffer from celiac disease.


Sucrose Intolerance Test

Sucrose (common table sugar) is a disaccharide composed of glucose and fructose. It is found in sugar cane, sugar beets and many fruits & vegetables. The enzyme sucrase (also called sucrase-isomaltase, saccharase or invertase) is present in both animal and plant tissues, and hydrolyzes sucrose into its two component monosaccharides.


Lactose Intolerance Test

Lactose intolerance is the inability to digest lactose. Lactose is the sugar found in dairy products such as milk and other dairy foods. Intolerance to lactose typically lead to symptoms such as gas, bloating, diarrhea or cramping when dairy products are digested. These symptoms are a result of the body's lack of lactase, an enzyme normally produced by the small intestine that is needed to digest lactose.

Online Order Access Here

Clinician Resources

Requisition Forms, Sample Reports & Test Instructions

For Clinicians & Providers

Resources Page

Patient Resources

Preparations before collecting a sample & instructions using our kit

For Patients

Resources Page Order A Kit

Breath Tests & Digestive Problems

What do breath tests have to do with digestive problems?

Resources Page


"At Aerodiagnostics,LLC we strive to provide accurate and timely information you and your family can depend on. We empathize with the challenges you face managing symptoms related to your gastrointestinal disorder(s). Our passion drives us to minimize your time in the process of diagnosis so together with your health care provider, you can resolve your symptoms quickly and accurately. Our mission is Advancing Healthcare into Human Care.”

Gary M. Stapleton, MBA

Chief Executive Officer

State of the Art Technology

Aerodiagnostics,LLC Breath Tests utilize non-invasive Hydrogen & Methane devices and a proprietary analysis that minimize false reports commonly found with invasive blood tests and hydrogen only breath tests. Aerodiagnostics,LLC's state-of-the-art & highly accurate diagnostic equipment incorporates a CO2 correction factor technique that minimizes error by improper sampling technique.

Our Breath Collection Kits Are Easy To Use

The EasySampler™ Breath Collection Kit is an approved and popular method for at home breath collection. This patented breath-collection kit allows patients to collect samples unsupervised and mail their breath samples back to the Aerodiagnostics,LLC for analysis. Patients enjoy the ease of collection that can be performed on their time, wherever they choose. Clinicians and staff enjoy that patients are afforded the flexibility to test at a location convenient for them.



Gary M. Stapleton

CEO & Founder


Kathleen O'Neil-Smith M.D.

Medical Director


Aerodiagnostics,LLC Laboratory

Executive Biographies

  • Gary Stapleton is the founder of Aerodiagnostics,LLC
  • Previously, Gary served as the Chief Operating Officer for Calloway Laboratories, a Massachusetts based national toxicology laboratory. In his COO role at Calloway, Gary was successful resurrecting a urine drug monitoring business by increasing commercial access through effective model transition and by attracting new and innovative diagnostic tests.
  • Gary began his career in the early 90's with Astra USA, later AstraZeneca (AZ). He held numerous positions in his 14 years with AZ including sales, marketing, training, managed care contracting, executive account management, and senior sales management positions. Gary was integral in the successful launches of blockbuster pharmaceuticals including Prilosec, Nexium, Seroquel, Symbicort, Crestor, Rhinocort, Toprol-XL, Naropin, EMLA Cream, Arimidex, Accolate, Atacand, Pulmicort, Zomig, and Zestril.
  • In 2007, he was recruited to Bausch & Lomb to lead the sales and marketing effort for B&L's branded pharmaceuticals as the Vice President of Sales and Marketing in the United States. At Bausch & Lomb, Gary successfully led the commercial effort taking the branded and generic portfolios to record levels.
  • Caris Life Sciences recruited him in 2009 to lead the growth strategy for the subspecialty (Gastroenterology, Dermatology, & Urology) anatomic pathology divisions. He launched the commercial Exosome offering, Caris' first molecular diagnostic.
  • Following his success at Caris Life Sciences, Gary served as the Chief Executive Officer at Lerner Medical Devices. He was specifically chosen by the founder to position Levia (Lerner's flagship product) prominently in the marketplace.
  • Prior to his extensive career in commercial health care, Gary served in the United States Marine Corps, initially stationed at Twentynine Palms, California after boot camp at Parris Island South Carolina.
  • He did his undergraduate work at Long Island University followed by a Masters in Business Administration. After many years in the health care space, Gary is excited to launch Aerodiagnostics,LLC providing the highest level of diagnostic accuracy and customer service for patients and clinicians.
  • Dr. Kathleen O'Neil-Smith is an internationally recognized clinician, educator, and consultant in the field of integrative medicine. She is best known for her expertise in personalized integrative therapies for underlying chronic issues that keep people from feeling healthy and vibrant.
  • Dr. O'Neil-Smith is a magna cum laude graduate of Boston University School of Medicine. She completed postgraduate training in pathology at Harvard's Massachusetts General Hospital and in internal medicine at the Brigham and Women's Hospital in Boston.
  • She has a B.S.in exercise physiology and has been an athlete on the national rowing team for 39 years and a coach for 6 years. She worked as an office and hospital-based internist. In 2008, she shifted to Functional and Regenerative Medicine after completing a 2 year fellowship at A4M. She recently completed fellowships in stem cell therapy through A4M and a TBI certification through AMMG.
  • Dr. O'Neil-Smith has extensive personal use of peptides and stem cells in her private medical practice. She also treated her only son with peptides when he had a severe TBI with a slim prognosis for healthy recovery. He recently graduated with a math degree, two years after that TBI.
  • She has served on the faculties of Tufts University's and Boston University's medical schools. Presently, she has a direct access practice in Functional, Integrative and Regenerative Internal Medicine in Boston for over ten years
  • Dr. O'Neil Smith is an international thought leader in the clinical use of peptide therapy. She is a compassionate, innovative, inspirational physician who is dedicated to offering the most cutting-edge safe therapies to her patients and helping others do the same.

see what patients are saying

"Thanks! We are so grateful for Gary and the team at Aerodiagnostics. He has been a wonderful resource for our clinic and we appreciate his willingness to always be of assistance to us and our patients when needed."

T.H. - RNTexas

"Aerodiagnostics has been the best lab I've ever worked with and I'll pass the word to all of my group forums. Thank you so much for being responsive, quick in processing and friendly."


"Thanks for the references! You have a great service!"


"Gary, on Tuesday of this week I referred a patient to Aerodiagnostics who previously tested positive twice for SIBO then was attempting to have a breath test at another facility but had a very difficult time receiving information from the staff. After speaking at length with her, she ultimately wanted to test at home so I provided the phone number for AerodiagnosticsTM and advised her I was placing her in the best hands possible and that she would be treated exceptionally well (all true).

The patient called me this afternoon to thank me for referring her to Aerodiagnostics and stated that she had an amazing, outstanding, positive experience working with your group. I am not certain whom she spoke with but she stated all her questions were answered in a professional, educated, and very friendly manner and she very much appreciated the way she was treated. She also stated it was very refreshing to be treated so well by Aerodiagnostics as she often felt 'lost or like another number instead of a person' when working with most medical groups. She felt like the individual she spoke with genuinely cared and was eager to assist and did not rush her during the call. As she has other friends with similar health issues, she is happily referring them to Aerodiagnostics for assistance and is also advising her physician of her experience with Aerodiagnostics and the services you offer.

I wanted to share this praise with you as too many times an organization that offers such outstanding service never truly knows the impact they have on their clients, you and your staff are making a very positive difference in the lives of many.

Thank you for all that you and your staff do, very best regards to all!


Hi Gary. Thanks so much for your help the other day. I have to say compared to any other lab we work with, the support you offer is second to none. We actually did a SIBO event last week where there were patient examples of people recovering from SIBO and getting great results. I stood up and presented about Aerodiagnostics being the most accurate SIBO test available.

A.P. - ProviderBoston

Goodness, I didn't expect to hear from you so quickly. It's late here! Thank you again! The Dr. and I wish most of the people we worked with were half as good and cared as much as you do.


A few words about us

Aerodiagnostics,LLC was founded in June 2014 to serve patients' unmet needs. Patients confronted with gastrointestinal symptoms often suffer in silence for many years without resolution.

Patients who seek medical advice are routinely required to travel to clinics or hospitals typically located in urban areas. The Hydrogen ONLY (versus Aerodiagnostics,LLC's Hydrogen & Methane) tests performed by many of these clinics and hospitals require the patent to schedule an appointment during the week and at a time that is convenient for the clinic or hospital staff. Additionally, these sites relegate the patient to more than three hours of testing with little to do in-between specimen collections.

These sites do not offer wifi or a quiet place to work or study during the test. Aerodiagnostics,LLC offers several convenient testing options. Our patients can take our tests in the convenience of their own home or place of employment. Aerodiagnostics,LLC friendly & experienced staff offer patient assistance from 9:00am ET - 6:30pm ET, Monday through Friday and after hours assistance via scheduled appointments.

— Aerodiagnostics,LLC

Frequently Asked Questions

  • Clinicians: You can call, email or chat with one of our Customer Service Representatives to set up an account and receive customized laboratory requisitions. Blank laboratory requisitions can also be download Here

  • Patients: If you would like to order a test for yourself, you may provide a laboratory requisition to you provider, or you may order one through our online store. Please note, for online orders, you would not be able to submit through insurance.

  • We bill Medicare and Tricare. Original Medicare requires an Advanced Beneficiary Notice (ABN). All Medicaid Plans should use our "No Insurance Option." Please complete sections 6&7 of the Aerodiagnostics,LLC Laboratory Requisition.

  • We bill all commercial plans with an initial payment of $99.74. Please complete sections 6&7 of the Aerodiagnostics,LLC Laboratory Requisition. We would not be able to tell you your exact coverage as every insurance plan is different. Please contact Aerodiagnostics,LLC's Customer Service for CPT codes, which you can present to your insurance company to determine your level of coverage.

  • You can pay by cash, check, money order, or credit card. If you have any additional questions about billing or payment, you can call, email, or chat with one of our Customer Service Representatives
  • Breath Collection Kits ship using two (2) business day shipping with FedEx. It may take an additional day if you live in Alaska, Hawaii or in a more rural area.

  • We are not able to ship to PO Boxes. Please contact Aerodiagnostics,LLC's Customer Service with any additional shipping questions.
  • You must wait at least 24 hours between each breath collection kit completion to allow for proper test preparation. This is to ensure that your results are accurate.
  • Please do not hesitate to call us directly with any questions or if we can be of any assistance. We have two convenient videos that are approximately two minutes in length. These videos were designed to assist patients with questions related to breath testing and the process to collect a breath specimen.

  • Please feel free to use the links to access these videos:
  • Hydrogen & Methane Breath Testing
  • Collection Procedures

  • If you have any further questions, feel free to call, email or chat with one of our Customer Service Representatives. We are happy to answer any and all of your questions!
  • Please ensure you have included the following in the box before shipping: Labeled glass vials in provided bubble wrap and the completed requisition form. Please feel free to also return the collection device and any additional paperwork.

  • Once you have packaged your breath specimens, place the prepaid FedEx return label on the outside of the white box and bring it to any FedEx dropbox (A mailbox for FedEx) or a FedEx facility. Click here to find the FedEx location closest to you. Customers shipping from outside of the United States may use the shipping method of their choice.

  • If you are missing any contents from your breath collection kit, please call, email, or chat with our Customer Service team and we would be happy to assist you.
  • Once we receive your specimens in our laboratory, the typical turnaround time for results is 24 business hours.

  • Results are sent directly to the ordering clinician.

  • If you ordered the test online, then the results will be sent directly to you.

  • Massachusetts State Law prohibits Aerodiagnostics,LLC from releasing results directly to patients without authorization from the ordering clinician. If your test was ordered through a clinician and you would like a copy of your results, please contact Aerodiagnostics,LLC's Customer Service. We will happily contact your clinician on your behalf to request approval.

  • All returns must be authorized by Aerodiagnostics,LLC prior to return.

  • Products must be returned within 30 days of online purchase.

  • Product Return Authorizations (PRAs) may be arranged by calling our Customer Service department at (844) 681-9449 or (617) 608-3832 or email customerservice@aerodiagnostics.com. Product Return Authorizations (PRAs) are valid for 15 calendar days.

  • To obtain a PRA, through Aerodiagnostics,LLC the following information must be provided for each return:
  • *Customer Name and Address
  • *Original confirmation of order delivered to customer via email at the time of the online order.
  • *Lot number and expiration date of each product to be returned.

  • An issuance of a PRA does not guarantee a refund. Refund issuance is dependent on confirmed receipt/review of returned products and is subject to other terms of this policy.

  • The following conditions will not be considered for return.
  • *Product purchased more than 15 days prior to the return request.
  • *Product is in any manner broken, breached or damaged.
  • *Products with less than 6 months shelf life remaining based on expiration dates.

  • Unauthorized returns may be:
  • *Returned to customer at customer’s expense.
  • *Destroyed by Aerodiagnostics,LLC at Aerodiagnostics,LLC’s discretion.
  • *Or subject to additional charges without a refund being issued to customer.

  • If a refund is approved all shipping cost will be deducted from the overall refunded amount.